Pygaba 75

Pregabalin

Central & peripheral neuropathic pain in adults including diabetic peripheral neuropathy & post-herpetic neuralgia. Adjunctive therapy in adults w/ partial seizures w/ or w/o secondary generalization. Generalized anxiety disorder in adults. Management of fibromyalgia.

150-600 mg daily in 2 or 3 divided doses. Adult Neuropathic pain Initially 150 mg daily. May be increased to 300 mg daily after an interval of 3-7 days up to a max dose of 600 mg daily after an additional 7-day interval. Epilepsy Initially 150 mg daily. May be increased to 300 mg daily after 1 wk. Max: 600 mg/day after an additional wk. Generalized anxiety disorder 150-600 mg daily as 2 or 3 divided doses. Initially 150 mg daily & may be increased to 300 mg daily after 1 wk. Following an additional wk, may be increased to 450 mg daily. Max dose: 600 mg daily. Fibromyalgia Usual dose range: 300-450 mg daily in 2 divided doses. Initially 75 mg bid & may be increased to 150 mg bid w/in 1 wk. May be further increased to 225 mg bid if experience is not sufficient w/ 300 mg/day. Max dose: 600 mg daily after an additional wk. Renal impairment (CrCl ≥60 mL/min) Starting dose: 150 mg/day as bid or tid. Max dose: 600 mg/day bid or tid, ≥30 to <60 mL/min Starting dose: 75 mg/day as bid or tid. Max dose: 300 mg/day bid or tid, ≥15 to <30 mL/min Starting dose: 25-50 mg once daily or bid. Max dose: 150 mg daily or bid, <15 mL/min 25 mg once daily. Max dose: 75 mg/day. Patients on hemodialysis Supplementary starting dose: 25 mg daily. Max dose: 100 mg daily.

May be taken with or without food.

Hypersensitivity.

Discontinue if hypersensitivity reactions occur. May cause hematologic disorder. Concomitant use w/ antidiabetics especially in patients w/ prior CV diseases. Visual disturbances may occur. Abrupt cessation may lead to insomnia, nausea, headache anxiety, hyperhidrosis & diarrhea, & increased seizure frequency. History of drug abuse. Hepatic or renal impairment. Do not drive or operate other complex machinery & take alcohol during therapy. Pregnancy & lactation.

Peripheral edema; dizziness, somnolence, ataxia, headache, fatigue; wt gain, xerostomia; tremor; blurred vision, diplopia; infection, accidental injury. Edema, chest pain, HTN, hypotension; neuropathy, abnormal thinking, confusion, euphoria, speech disorder, attention disturbance, amnesia, incoordination, pain, insomnia, impaired memory, vertigo, hypoesthesia, abnormal feeling, anxiety, lethargy, feeling drunk, disorientation, depersonalization, fever, hypertonia, sedation, stupor, nervousness; constipation, increased appetite, nausea, flatulence, vomiting, abdominal distention, abdominal pain, gastroenteritis; balance disorder, abnormal gait, weakness, arthralgia, twitching, muscle spasm, back pain, myoclonus, increased CPK, neck pain, pain in extremity, joint swelling, paresthesia, leg cramps, myalgia, myasthenia; decubitus ulcer, facial edema, bruising, pruritus; fluid retention, hypoglycemia, decreased libido; incontinence, anorgasmia, impotence, urinary frequency; thrombocytopenia; visual abnormalities, eye disorder, conjunctivitis, nystagmus; nasopharyngitis, sinusitis, pharyngolaryngeal pain, bronchitis, dyspnea; flu-like syndrome, allergic reaction.

Potential increased risk of wt gain & peripheral edema w/ thiazolidinediones. Potential additive effects on cognitive & gross motor functioning w/ lorazepam, oxycodone & alcohol. Potential increased risk of developing angioedema w/ ACE inhibitors. Potential additive CNS depressant effects of CNS depressants eg, opiates & benzodiazepines.

Anticonvulsants / Anxiolytics / Drugs for Neuropathic Pain

N02BF02 - pregabalin ; Belongs to the class of gabapentinoids. Used to relieve pain and other conditions.

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